Australian scientists have identified the immune response that determines why some mice are infected with mousepox and others are not, a discovery that could lead to better protection for humans in a bio-terror attack. Mice that are resistant to mousepox, a close relative of the smallpox virus, produce three regulatory proteins called cytokines that are absent in mice that become infected. The findings raise the possibility of identifying humans vulnerable to smallpox and targeting vaccination and treatment in the event of an outbreak, said Australian National University immunologist Gunasegaran Karupiah, who headed the discovery team. Full Story
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