“In 2009, one or more prestigious researchers received a CD by mail that contained pictures and other materials from a recent scientific conference they attended in Houston. The scientists didn’t know it then, but the disk also delivered a malicious payload developed by a highly advanced hacking operation that had been active since at least 2001. The CD, it seems, was tampered with on its way through the mail.”
Source: How “omnipotent” hackers tied to NSA hid for 14 years—and were found at last | Ars Technica